KVV E-Modules

Which of the following best explains why crystalline drug forms are generally more stable than amorphous forms?

A: Crystalline forms have higher entropy B: Crystalline forms exist at a higher free energy level C: Crystalline forms represent the global minimum of free energy D: Crystalline forms show higher molecular mobility

The glass transition temperature (Tg) of an amorphous drug represents:

A: The temperature at which the crystal lattice collapses B: The temperature at which chemical degradation starts C: The transition from a rigid glassy state to a rubbery viscous state D: The temperature of solvent evaporation

In Differential Scanning Calorimetry (DSC), cold crystallization of an amorphous drug appears as:

A: A baseline shift B: An endothermic peak C: An exothermic peak D: No thermal event

Which of the following statements about pharmaceutical co-crystals is correct?

A: Co-crystals involve complete proton transfer B: Co-crystals are formed only for ionizable drugs C: Co-crystals consist of an API and a neutral co-former held by hydrogen bonds D: Co-crystals always show higher hygroscopicity than salts

In the “Spring and Parachute” concept, the role of polymers in the formulation is to:

A: Increase crystallinity of the drug B: Reduce dissolution rate C: Prevent precipitation and maintain supersaturation D: D. Lower the melting point of the drug