KVV E-Modules

1. Structure Activity Relationship

1. Structure Activity Relationship

1.Define Structure–Activity Relationship (SAR) and explain its concept and importance in drug design and development. 2. Discuss the various factors considered in SAR studies and explain how these factors influence biological activity. 3. Explain the modification of the parent compound in SAR with suitable examples. How does structural modification affect drug activity and toxicity? 4. Describe the role of functional groups in SAR. Discuss the contribution of alkyl, hydroxyl, amino, and halogen groups in determining drug activity.