KVV E-Modules

1. The pKa of a drug is defined as:

A: A. pH at which drug is completely ionized B: B. pH at which drug is completely unionized C: C. pH at which 50% drug is ionized D: D. pH of maximum solubility

2. According to the pH–partition hypothesis, drug absorption is maximum when the drug is:

A: A. Ionized B: B. Unionized C: C. Protein bound D: D. Hydrophilic

3. A weak acid drug with pKa = 4 will be mostly unionized at:

A: A. pH 7 B: B. pH 6 C: C. pH 2 D: D. pH 8

4. A weak base drug is best absorbed in:

A: A. Stomach B: B. Intestine C: C. Blood D: D. Liver

5. When pH > pKa for a weak acid drug, the drug will be:

A: A. Unionized B: B. Ionized C: C. Neutral D: D. Insoluble

Which type of instability involves hydrolysis and oxidation?

A: Physical instability B: Biological instability C: Chemical instability D: Mechanical instability