KVV E-Modules - Steroids

Quadrant -I (Video)

Quadrant 1 Video lecture: Basics of Steroids

Quadrant - II (Study Material)

1. Quadrant 2: Study Material steroids

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Quadrant - III (Assignments)

1. Quadrant 3: Assisgment on Steroids

Assignment: Drugs Acting on the Endocrine System 1. Explain the nomenclature and structure of corticosteroids. Discuss the general structure of steroids and how specific corticosteroids (Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone) are named based on their chemical modifications. 2. Describe the stereochemistry of corticosteroids. Provide a detailed explanation of how the stereochemistry of corticosteroids influences their biological activity, focusing on key positions in the steroid nucleus that affect drug efficacy. 3. Metabolism of Corticosteroids: How are they processed in the body? Elaborate on the metabolic pathways for corticosteroids like cortisone, hydrocortisone, prednisolone, betamethasone, and dexamethasone. Include details on oxidation, reduction, and hydroxylation. 4. Compare and contrast the pharmacological actions of Cortisone, Hydrocortisone, Prednisolone, Betamethasone, and Dexamethasone. What are the key differences in their therapeutic uses and potency? 5. Discuss the clinical applications of corticosteroids. Choose two corticosteroids and explain their clinical applications, focusing on how their structure and metabolism affect their use in conditions like inflammation, allergies, and autoimmune diseases.

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Quadrant - IV (MCQs)

Which of the following is the active form of Cortisone? a) Prednisolone b) Hydrocortisone c) Betamethasone d) Dexamethasone

A: a) Prednisolone B: b) Hydrocortisone C: c) Betamethasone D: d) Dexamethasone

What structural change in Prednisolone increases its anti-inflammatory activity compared to Hydrocortisone? a) Addition of a methyl group at position …

A: a) Addition of a methyl group at position 16 B: b) A double bond between C1 and C2 C: c) Fluorine substitution at position 9 D: d) Conversion of keto group to hydroxyl group at C11

Which corticosteroid is most commonly used for long-term treatment of autoimmune diseases? a) Dexamethasone b) Hydrocortisone c) Prednisolone d) Cortisone

A: a) Dexamethasone B: b) Hydrocortisone C: c) Prednisolone D: d) Cortisone

Which enzyme primarily metabolizes corticosteroids in the liver? a) CYP450 enzymes b) Amylase c) Protease d) Lipase

A: a) CYP450 enzymes B: b) Amylase C: c) Protease D: d) Lipase

What effect does the fluorine substitution at C9 have on Betamethasone and Dexamethasone? a) Decreases their potency b) Increases anti-inflammatory …

A: a) Decreases their potency B: b) Increases anti-inflammatory activity C: c) Shortens their duration of action D: d) Decreases their bioavailability

Validation Certificates

1. E content module Certificate(Validation part 1))

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2. E content module certificate (Validation part II)

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3. Checking Report

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