KVV E-Modules - Selection of drug candidates for CRDDS

Quadrant -I (Video)

Selection Of Drug Candidates For CRDDS

Quadrant - II (Study Material)

1. Selection of drug candidates for CRDDS

View File

Quadrant - III (Assignments)

1. Selection of drug candidates for CRDDS

[1] Explain the concept and importance of Controlled Release Drug Delivery Systems (CRDDS). Discuss how CRDDS improves therapeutic outcomes and patient compliance. [2] Describe in detail the physicochemical properties of a drug that influence its suitability for formulation into a CRDDS. Support your answer with appropriate examples. [3] Discuss the role of biological factors such as half-life, therapeutic index, and protein binding in the selection of drug candidates for CRDDS. Why are drugs with a narrow therapeutic index generally unsuitable? [4] Compare and contrast drugs that are suitable vs. unsuitable for CRDDS based on the Biopharmaceutics Classification System (BCS), molecular weight, and absorption characteristics. [5] Evaluate the challenges in formulating controlled release systems for drugs with poor aqueous solubility and extensive first-pass metabolism. Suggest strategies to overcome these limitations.

Quadrant - IV (MCQs)

Drugs with ———therapeutic index are unsuitable for incorporation in controlled release formulation.

A: High B: Low C: Moderate D: None

Zero order release kinetics is attained in...

A: Sustain Release B: Controlled Release C: Intermediate Release D: None

Drug having molecular weight —————— is good candidate for controlled release dosage form

A: More than 2000 dalton B: Less than 400 dalton C: More than 1000 dalton D: Less than 2000 dalton

Ideally, the drug should have half-life to be formulated in controlled release dosage

A: 2-6 hrs B: 1-2 hrs C: 6-7 hrs D: 9-10 hrs

Release kinetics from dissolution control system is governed by.........

A: Fick’s law of diffusion B: Noyes Whitney equation C: First order D: Second order

Validation Certificates

1. E-content module certificate-I

View File

2. E-content module certificate-II

View File

3. Checking report

View File