KVV E-Modules - Polymorphism in pharmaceutical sciences

Quadrant -I (Video)

Polymorphism in pharmaceutical sciences

Quadrant - II (Study Material)

1. Polymorphism in pharmaceutical sciences

Quadrant - III (Assignments)

1. Polymorphism in pharmaceutical sciences

1.Define polymorphism. Discuss factors influencing polymorphic form and give its importunate in pharmaceutical sciences. 2.Explain working principles and applications of analytical techniques used to determine type of polymorphic form. 3.Discuss the role of computational modeling and molecular simulation in predicting polymorphism. 4.Differentiate between crystalline and amorphous solids. 5.Differentiate between true polymorphism and pseudo-polymorphism.

Quadrant - IV (MCQs)

True polymorphism refers to:

A: Crystal forms containing solvent molecules B: Different crystalline forms without solvent inclusion C: Hydrated crystalline forms D: Amorphous structures

Pseudo-polymorphism occurs due to:

A: Inclusion of solvent molecules in crystal lattice B: Change in chemical formula C: Different molecular weight D: Presence of impurities

When water molecules are incorporated into the crystal lattice, the form is called:

A: Solvate B: Polymorph C: Hydrate D: Anhydrate

The temperature at which two polymorphs have equal free energy is called:

A: Critical temperature B: Transition temperature C: Melting temperature D: Decomposition temperature

Which technique is considered the gold standard for identifying crystalline forms?

A: DSC B: PLM C: XRPD D: TGA

Polarized light microscopy identifies crystalline materials based on:

A: Diffraction peaks B: Birefringence C: Heat flow D: Mass change

Crystal Structure Prediction (CSP) is used to:

A: Predict possible crystal packing arrangements B: Determine chemical structure C: Measure melting point D: Determine dissolution rate

High-throughput polymorph screening involves:

A: Single crystallization experiment B: Multiple crystallization experiments under varied conditions C: Only thermal analysis D: Only computational analysis

Dilatometry measures:

A: Heat flow B: Volume change with temperature C: Diffraction angle D: Infrared absorption

In XRPD analysis, amorphous materials produce:

A: Sharp peaks B: Endothermic peak C: Exothermic peak D: Diffused hump

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