KVV E-Modules

Quadrant -I (Video)

Pathophysiology and Mechanism of Addiction

Quadrant - II (Study Material)

1. Pathophysiology and Mechanism of Addiction

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2. Additional study material

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Quadrant - III (Assignments)

1. Pathophysiology and Mechanism of Addiction

1. Define addiction and explain its main features. 2. Describe the brain reward pathway involved in addiction. 3. What neurotransmitters are implicated in the neurobiology of addiction? 4. Explain the difference between tolerance and dependence. 5. What is pharmacokinetic tolerance and how does it occur? 6. Name some drugs that cause enzyme induction leading to pharmacokinetic tolerance. 7. Define physical dependence and describe its clinical significance. 8. What neuroadaptations occur in the brain during opioid dependence? 9. How does chronic alcohol use affect GABA and NMDA receptors? 10. Distinguish between physical and psychological dependence.

Quadrant - IV (MCQs)

Which brain pathway is central to addiction due to its role in dopamine release?

A: Corticospinal pathway B: Spinothalamic tract C: Mesolimbic dopamine pathway D: Reticulospinal pathway

Which neurotransmitter plays a key role in the brain reward pathway involved in addiction?

A: Dopamine B: Acetylcholine C: Norepinephrine D: Histamine

Tolerance to a drug is best described as:

A: Increased effectiveness of a drug over time B: Reduced effectiveness requiring higher doses for the same effect C: Withdrawal symptoms when drug use is stopped D: Psychological craving only

Pharmacokinetic tolerance is caused by:

A: Receptor desensitization B: Enzyme induction or inhibition affecting drug metabolism C: Increased receptor sensitivity D: Genetic mutations

Which of these drugs commonly cause enzyme induction leading to pharmacokinetic tolerance?

A: Barbiturates, phenytoin, rifampicin B: Benzodiazepines, opioids C: Cocaine, amphetamines D: Antidepressants

Physical dependence on a drug is characterized by:

A: Intense physical symptoms upon withdrawal B: Psychological craving only C: Occasional use without symptoms D: Increased tolerance but no withdrawal symptoms

Neuroadaptation in opioid dependence involves:

A: Increased dopamine release during withdrawal B: Receptor internalization and desensitization C: Increased postsynaptic receptor activation D: Decreased GABA release during withdrawal

Chronic alcohol use affects neurotransmitter systems by:

A: Enhancing NMDA receptor activity B: Downregulating GABA-A receptors and upregulating NMDA receptors C: Suppressing glutamate receptors permanently D: Increasing serotonin receptor sensitivity

Psychological dependence on a drug refers to:

A: Adaptive body state with physical symptoms on withdrawal B: Receptor desensitization C: Satisfaction and psychic drive requiring continued drug use D: Complete absence of withdrawal symptoms

Quadrant -I (Video)

Pathophysiology and Mechanism of Addiction

Quadrant - II (Study Material)

1. Pathophysiology and Mechanism of Addiction

2. Additional study material

Quadrant - III (Assignments)

1. Pathophysiology and Mechanism of Addiction

Quadrant - IV (MCQs)

Which brain pathway is central to addiction due to its role in dopamine release?

Which neurotransmitter plays a key role in the brain reward pathway involved in addiction?

Tolerance to a drug is best described as:

Pharmacokinetic tolerance is caused by:

Which of these drugs commonly cause enzyme induction leading to pharmacokinetic tolerance?

Physical dependence on a drug is characterized by:

Neuroadaptation in opioid dependence involves:

Chronic alcohol use affects neurotransmitter systems by:

Psychological dependence on a drug refers to:

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