KVV E-Modules

What is the partition coefficient in the context of pharmaceutical chemistry?

A: A) The ratio of a drug's solubility in air to its solubility in water B: B) The ratio of the concentration of a compound in two immiscible solvents at equilibrium C: C) The ratio of a drug's solubility in blood to its solubility in tissu D: D) The ratio of a drug's solubility in oil to its solubility in water

The term "partition coefficient" is often used to describe the distribution of a drug between

A: A) Solid and liquid phases B: B) Liquid and vapor phases C: C) Two immiscible liquid phase D: D) Gas and solid phases

The partition coefficient (P) is commonly expressed in the form of:

A: A) P = Cp/Co B: B) P = Co/Cw C: C) P = Cw/Cl D: D) P = Cl/Co

What does a partition coefficient greater than 1 indicate about a drug?

A: The drug is more hydrophilic B: The drug is more lipophilic C: C) The drug is equally soluble in both pha D: D) The drug has low solubility

According to Nernst's Distribution Law, the ratio of concentrations of a solute in two immiscible solvents is:

A: A) Dependent on the total amount of solute B: Constant at a given temperature C: C) Variable with changes in pr D: D) Independent of temperature

Which of the following is a limitation of the Nernst Distribution Law?

A: A) It can only be applied to ionic solutes B: B) It assumes mutual solubility of solvents C: C) It requires the solute to be present at high concentration D: D) It assumes the solute remains in the same molecular state in both solvents