KVV E-Modules - Cell-Cycle specific antimetabolite anticancer drugs

Quadrant -I (Video)

Cell-Cycle specific antimetabolite anticancer drugs

Quadrant - II (Study Material)

1. Cell-Cycle specific antimetabolite anticancer drugs

Quadrant - III (Assignments)

1. Cell-Cycle specific antimetabolite anticancer drugs

Q1. Explain the mechanism of action, pharmacological effects, adverse effects, and clinical use of Methotrexate. Also discuss the role of Leucovorin rescue therapy in reducing toxicity. Q2. Describe the classification of antimetabolite anticancer drugs with suitable examples. Explain how these drugs interfere with DNA synthesis during the S-phase of the cell cycle and discuss mechanisms of resistance developed by cancer cells.

Quadrant - IV (MCQs)

1. Antimetabolites are best described as:

A: Drugs that destroy cell membranes directly B: Structural analogues of normal cellular metabolites C: Hormonal agents inhibiting tumor growth D: Enzyme activators in cancer cells

2. Antimetabolite drugs are primarily active in which phase of the cell cycle?

A: G1 phase B: G2 phase C: M phase D: S phase

3. Methotrexate exerts its anticancer effect by inhibiting:

A: DNA polymerase B: Thymidylate synthase C: Dihydrofolate reductase D: Xanthine oxidase

4. The mechanism of action of 5-Fluorouracil involves inhibition of:

A: DNA polymerase B: Thymidylate synthase C: RNA polymerase D: Topoisomerase

5. When 6-Mercaptopurine is administered with Allopurinol, what adjustment is required?

A: Increase dose of 6-MP B: No change required C: Reduce dose of 6-MP D: Stop Allopurinol

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