KVV E-Modules

Which phase of the cell cycle is primarily targeted by vinca alkaloids and taxanes?

A: G1 phase B: S phase C: G2 phase D: M phase

Vinca alkaloids exert their anticancer action primarily by:

A: Inhibiting DNA synthesis B: Inhibiting microtubule polymerization C: Enhancing microtubule stabilization D: Inhibiting topoisomerase II

The primary mechanism of action of taxanes is:

A: Inhibition of tubulin polymerization B: Stabilization of microtubules and inhibition of depolymerization C: Inhibition of DNA replication D: Alkylation of DNA

Which adverse effect is most commonly associated with vincristine therapy?

A: Severe nephrotoxicity B: Ototoxicity C: Peripheral neuropathy D: Cardiomyopathy

Which adverse effect is dose-limiting for taxanes such as paclitaxel?

A: Neurotoxicity B: Hepatotoxicity C: Myelosuppression D: Nephrotoxicity

Resistance to vinca alkaloids and taxanes commonly occurs due to:

A: Increased drug uptake B: Overexpression of P-glycoprotein efflux pumps C: Increased DNA repair D: Increased angiogenesis