KVV E-Modules

1. Drug design primarily involves:

A: Random synthesis of compounds B: Identification of the biological target and optimization C: Only clinical trials D: Marketing of drugs

6. Structure–Activity Relationship (SAR) studies help to:

A: Manufacture drugs B: Determine the price of drugs C: Relate chemical structure to biological activity D: Store drugs

2. A pharmacophore is:

A: Minimum structural features required for activity B: A toxic group in a drug C: Side effect causing group D: Inactive part of the molecule

3. Which of the following is NOT a factor affecting SAR?

B: Electronic effects B: Steric effects C: Hydrophobicity D: Packaging material

4. Ligand-Based Drug Design is used when:

A: The target structure is known B: The target structure is unknown C: The drug is already marketed D: The toxicity is high

5. In ACE inhibitors, the thiol (-SH) group in Captopril is important for:

A: Zinc binding B: Solubility C: Color D: Stability

7. Which drug was developed to reduce the antiandrogenic effects of Cimetidine?

A: Aspirin B: Propranolol C: Cisplatin D: Ranitidine

8. The transformation from isoproterenol to Propranolol is an example of:

A: Bioisosterism B: Prodrug formation C: Agonist to antagonist conversion D: Toxicity reduction

9. COX-2 selectivity in Celecoxib is due to:

A: Smaller size B: Bulky side chain C: Lack of functional groups D: Hydrophilic nature

10. Acyclovir shows selective toxicity because it is:

A: Active in all cells B: Highly toxic C: Lipid soluble D: Activated only in infected cells