KVV E-Modules - Buffered Isotonic Solutions: Class I & Class II Methods for Isotonicity Adjustments

Quadrant -I (Video)

Basic fundamental concepts of Mathematics

Quadrant - II (Study Material)

1. Study Material

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Quadrant - III (Assignments)

1. Assignment

Q1. Using the Cryoscopic Method, calculate the amount of sodium chloride required to make a 2% solution of a drug isotonic, if the drug depresses the freezing point by 0.10°C. (Given: Freezing point depression of plasma = 0.52°C, Depression by 1% NaCl = 0.576°C) Q2. Using the E-value method, calculate how much NaCl should be added to prepare 50 mL of an isotonic solution containing 0.8 g of a drug. (Given: E-value of the drug = 0.20) Q3. Use the Molecular Concentration Method to determine how much sodium chloride is osmotically equivalent to a 1% solution of urea. (Given: MW of urea = 60.06, i = 1; MW of NaCl = 58.5, i = 2) Q4. Using the White-Vincent Method, determine the volume of isotonic solution to be prepared from 0.75 g of a drug with an E-value of 0.16. Q5. Using the Sprowls’ Method, calculate how much isotonic solution needs to be added after dissolving 0.5 g of a drug in 10 mL water, if the drug’s E-value is 0.18.

Quadrant - IV (MCQs)

The freezing point of human blood plasma is:

A: 0.00°C B: -0.52°C C: –0.76°C D: –0.32°C

The van’t Hoff equation used in molecular concentration method is:

A: PV=nRT B: E=mc^2 C: C1×i1=C2×i2 D: Molarity=w/V

What is the dissociation factor (i) for NaCl?

A: 1 B: 0 C: 3 D: 2

The White-Vincent formula to calculate volume of isotonic solution is:

A: V=100×w B: V=111.1×w×E C: V=0.009×V D: V=w/E

When should Class II methods be used over Class I methods?

A: When the drug volume is unknown B: When the final volume is fixed C: When the drug has already been dissolved D: Both A and C

Validation Certificates

1. E-content Module Certificate (Validation Part I)

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2. E-content Module Certificate (Validation Part II)

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3. Checking Report

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